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Mixing Kratom and Melatonin: Potential Effects & Risks

November 29th, 2024CombosNo Comments »

Kratom users are often curious about pairing kratom with other supplements to enhance kratom’s effects. Of all these pairings, taking kratom with melatonin is a frequent discussion in the kratom community, especially for those seeking better quality sleep. Considering the properties of these two substances, how do they pair together and does the combo offer something more than either can offer on their own? That’s our focus in this writeup so read on as we unpack this topic.

What is Melatonin?

Naturally, melatonin is a hormone produced in the body, and its function is to regulate sleep wake cycles and to promote sleep. The body makes more melatonin in the dark and less in the presence of light. This mechanism clearly explains why you can more easily fall asleep in the dark.

Interestingly, melatonin can be made synthetically in the lab and due to this, producing it is very cost effective. Even though melatonin offers other potential health benefits, there is no solid scientific backing to support these claims. So for this article, our focus will be on using melatonin to improve sleep quality.

Combining Kratom and Melatonin: How Safe and Effective Is It?

Since both kratom and melatonin are known to promote relaxation and sleep, taking them together can produce an enhanced effect. While this sounds like what you may want to hear, this combo can also raise important safety considerations.

For your safety, we don’t recommend using kratom and melatonin for daytime use, and a main reason for this is the chance that the combo will make you feel dozy, and this can impair activities that require alertness.

image of combining kratom and melatoninHow often should you take melatonin and kratom together? Twice a week or less is preferable because you don’t want to attract the risk of habit formation, especially with prolonged use of kratom.

Ultimately, if you are new to the combination, you must be deliberate about your dosage, as both substances can have stronger effects when used in combo. Monitoring your dosage will help you get your desired effects and possibly prevent adverse effects. We’ll talk more about dosage recommendations as you read further.

Note: There is limited information on the effects of combining kratom and melatonin, and therefore we caution against using them together until more safety research exists. 

How do Melatonin and Kratom Potentially Work Together?

Before we dissect how both may work together inside our bodies, understanding their individual mechanisms of action is necessary. As stated earlier, melatonin is a hormone produced in response to light or darkness, which is a way to prepare your body for wake and sleep cycles. The hormone aligns with circadian rhythms that help regulate sleep-wake cycles and promote restful sleep.

Because melatonin has the capacity to make you feel dozy, it is commonly available as a supplement to address sleep disturbances, especially when aligned with a regular bedtime routine.

On the other hand, kratom is made up of alkaloids, and the two primary compounds are mitragynine and 7-hydroxymitragynine. These alkaloids, especially mitragynine, interact with certain receptors in the brain and central nervous system to influence mood, relaxation and energy levels. At low doses, kratom might improve your mood and energy, and at higher doses, it generally promotes relaxation and may sedate in some cases.

Now, combining kratom and melatonin can go in one of two ways: since kratom can have differing effects depending on the strain and dosage. Certain types and dosages of kratom may encourage calming effects and potentially make it easier to fall asleep due to this. On the other hand, strains and dosages of kratom that boost energy may be counterproductive to encouraging sleep.

Since red strains are generally known to promote relaxation, they my enhance melatonin’s calming effects and encourage a restful sleep. However, if you take white strain or certain green strains, which are known for boosting energy, then it may counter the effects of melatonin and make it harder to fall asleep.

image of kratom and melatonin effects on sleep quality and pattern

The Effects of Melatonin and Kratom on Sleep

If you are thinking of taking kratom together with melatonin, then be mindful of the type and dosage of kratom you are taking. When used together, melatonin works by regulating the sleep-wake cycle, while kratom can lead to calming and relaxation. The resultant effect of both combined can potentially help encourage sleep.

Nevertheless, their effects on REM cycles are different. While melatonin supports natural REM cycles, kratom may reduce REM sleep. A reduction in REM sleep may reduce the restorative and beneficial qualities of sleep, and this quality may become more pronounced with more heavy and frequent kratom use.

Practical Tips for Combining Kratom and Melatonin

The first thing to know about is the form in which you want to take these substances. Since both are available in capsule form, you want to match the forms to get consistency in dosing.

For dosing, it’s always advisable to start low with something you are new to. A low dose of melatonin (1-3 milligrams) and a moderate dose of kratom (3-5 grams) should be your starting point. You can gradually adjust it as needed to find what works best for you.

Red kratom should be your go-to type because reds have relaxing properties that may complement melatonin. Using energizing strains like whites or greens may not help encourage sleep and may have the opposite effect. You should take kratom about 30 minutes before the melatonin to help get you in a relaxed state.

In all, to get a better rest with these supplements, the key is adjusting and personalizing your doses and choosing the right kratom strain. The combo can work for people differently however, so it is important to be mindful of this.

image of practical tips for kratom and melatonin combination

The Potential Side Effects of Taking Kratom and Melatonin Together

Both kratom (red strains in particular) and melatonin may potentially help with relaxation before sleep. If you are new to taking these two  together and are not careful with your dosage, it may potentially cause excessive sleepiness and impairment. This may affect your activities the following morning, and lead to hangover-type symptoms.

Also, taking kratom frequently can lead to tolerance and dependency. You can help counteract this by starting with a low dose and adjusting it gradually, and avoiding daily use, with frequent breaks.

Final Thoughts

Taking kratom and melatonin together may improve relaxation before sleep. This is particularly great for people seeking solutions to wind down before bedtime. However, caution must be taken to avoid taking the wrong dosage and type of kratom, which may lead to the opposite effect.


CONTENT DISCLAIMER: The content on this page is strictly for entertainment purposes only. The content below has not been medically reviewed and is not intended to offer advice for use or intended use. For more information about kratom and its potential dangers, please visit the fda.gov site.

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